1. Identification of urinary biomarkers for type 2 diabetes using bead-based proteomic approach

Mon, 17 Jun 2013 20:05
Histidine triad nucleotide-binding protein 1, bifunctional aminoacyl-tRNA synthetase, and clusterin precursor protein may serve as potential biomarkers distinguishing type 2 diabetes mellitus patients from healthy controls (Diabetes Research and Clinical Practice)  
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2. The kidney as a new target for antidiabetic drugs: SGLT2 inhibitors

Mon, 17 Jun 2013 20:04
A sufficient number of clinical trials have been conducted on sufficiently chemically diverse SGLT2 inhibitors to reasonably conclude that they have efficacy (HbA1c reductions of 0·4–1%), and thus far, the majority of adverse effects have been mild and transitory or treatable, with the caveat of possible association with increased risk of breast cancer in women and bladder cancer in men (Journal of Clinical Pharmacy and Therapeutics)  
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3. Boehringer Ingelheim Pharmaceuticals, Inc. and Eli Lilly and Company Statement on the ADA Request for Independent Review of Incretin-Based Therapies

Sat, 15 Jun 2013 20:09
We welcome future discussion with the ADA to determine how best we can support this initiative and to provide a valuable contribution (Lilly)  
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4. Applying Current Screening Tools for Gestational Diabetes Mellitus to a European Population - Is it Time for Change?

Fri, 14 Jun 2013 17:56
This analysis provides a strong argument for universal screening. However, if selective screening were adopted, the American Diabetes Association guidelines would result in the highest rate of diagnosis and the lowest number of missed cases (Diabetes Care)  
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5. Diamyd expands its Scientific Advisory Board

Thu, 13 Jun 2013 19:28
Diamyd Medical recently acquired exclusive rights relating to the therapeutic use of GABA for the treatment of diabetes and other inflammation-related conditions (Diamyd Medical)  
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6. Obesity and kidney disease in type 1 and 2 diabetes: an analysis of the National Diabetes Audit

Thu, 13 Jun 2013 19:27
This study has highlighted a strong association between obesity and kidney disease in type 1 diabetes and confirmed their association in type 2 diabetes (QJM)  
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7. The Effect of Diabetes-Associated Autoantigens on Cell Processes in Human PBMCs and Their Relevance to Autoimmune Diabetes Development

Thu, 13 Jun 2013 19:27
These important immune response-related processes largely included the induction of Th17 and Th22 responses, as well as cytoskeletal rearrangements, MHCII presentation, and the upregulation of CD4, TGF-beta, and STAT3. These findings potentially suggest that these processes could be utilised as predictive markers for the development of T1D or as molecular targets for the repression of specific immunocompetent cell populations for the treatment of diabetes (Journal of Diabetes Research)  
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8. Retinal Layers Changes in Human Preclinical and Early Clinical Diabetic Retinopathy Support Early Retinal Neuronal and Müller Cells Alterations

Wed, 12 Jun 2013 16:37
Neuronal loss is accompanied (or induced) by Müller cells activation, with increasing thickness in the INL. Automatic intraretinal layering by spectral-domain optical coherence tomography may be a useful tool to diagnose and monitor early intraretinal changes in diabetic retinopathy (Journal of Diabetes Research)  
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9. The Diabetes‘Breathalyzer’

Tue, 11 Jun 2013 18:52
Pitt chemists demonstrate sensor technology that could detect and monitor diabetes through breath analysis alone (University of Pittsburgh)  
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10. Carotid ultrasonography: A potent tool for better clinical practice in diagnosis of atherosclerosis in diabetic patients

Tue, 11 Jun 2013 18:52
It is expected that carotid ultrasonography will become a potent tool for better clinical practice of atherosclerosis in diabetic patients (Journal of Diabetes Investigation)  
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11. Influence of macro- and microvascular comorbidity on time to insulin initiation in type 2 diabetes patients: A retrospective database analysis in Germany, France, and UK

Tue, 11 Jun 2013 18:51
A more rapid progression to insulin therapy was found in patients with microvascular complications (Primary Care Diabetes)  
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12. Relationship between type-2 diabetes and use of metformin with risk of colorectal adenoma in an American population receiving colonoscopy

Mon, 10 Jun 2013 18:55
Within diabetic patient group, people who were taking metformin have significantly lower risk of colorectal adenoma. Diabetic subjects have increased risk of developing colorectal adenoma. Our study also supports the beneficial effect of metformin in development of colorectal adenoma (Diabetes and Its Complications)  
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